Conférence Dr Sandrine Sarrazin - Immunomodulation and immune memory in HSC: new functions for new therapeutic applications?
2022-03-18 11:00 - 12:00 (Europe/Paris) | Salle Cazaux + Visio Teams
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Réservée à la communauté scientifique

Conférence Dr Eric Tartour - The two faces of CD8*T cells in cancer immunotherapy
2022-04-05 11:00 - 12:00 | Amphithéâtre IUCT-O
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Contact : celine.colacios@inserm.fr
Réservé à la communauté scientifique.

Conférence Dr Joel Plumas - Treatment of Non-Small Cell Lung Cancer patients with an innovative cell-based cancer vaccine, PDC*lung01
2022-04-15 11:00 - 12:00 | Amphithéâtre IUCT-O (& retransmission Starleaf)
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Contact : bruno.segui@inserm.fr

Séminaire Axe 2 : Diversity in rRNA 2’Ome profiles in cancer and impact on translational regulation - Virginie Marcel, CRCL (Lyon)
2022-05-10 13:30 - 14:30 | Visio Teams
Diversity in rRNA 2’Ome profiles in cancer and impact on translational regulation – Virginie Marcel
Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Université Lyon 1, Nuclear domains and pathologies team, Lyon, France
While the ribosome was considered for over 40 years as a neutral actor of gene expression, it now appears as a key regulator of translation through modulation of its composition, including via chemical modifications of ribosomal RNAs (rRNAs). In cellular models, we revealed that ribose 2’-Omethylation (2’Ome) of rRNA can be modulated in human and become a source of ribosome diversity. We reported that 2’Ome is altered during tumorigenesis and directly affects translational behavior of ribosomes toward mRNA subsets. However, whether alteration of rRNA 2’Ome occurs in “real-life” remained to be demonstrated. Thanks to an innovative omic technology, the RiboMETH-seq, we made the first demonstration that rRNA 2’Ome is altered in different cancer types, including breast cancer and glioma. It appears that variability in rRNA 2’Ome level is restricted to only a subset of positions. Moreover, comparison of several adult tumors indicates that most of these variable sites are common to different tumor sites while few of them are specific to particular cancer type. Our data support the recent entry of the ribosome into the emerging field of epitranscriptomics.
Selected references
(1) Marcel et al. (2013) Cancer Cell 24, 318-330.
(2) Erales et al. (2017) PNAS 114, 12934-12939.
(3) Marcel et al. (2020) NAR Cancer 2, 318.
(4) Jaafar et al. (2021) Cells 10, 1948.
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Séminaire Axe 4 : RNA-seq Analysis by inferring transcription factor activities, VIPER - Matthieu Genais (MELASPHNIX - B.Segui & N.Andrieu)
2022-05-24 13:30 - 14:30 | Salle Cazaux + Visio Teams
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Contact : matthieu.genais@inserm.fr

Conférence Dr Ilse Rooman : Pancreatic cancer origin and plasticity, a "masked ball" of exocrine cells
2022-06-10 11:00 - 12:00 | Salle Cazaux + Visio Teams
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Meet-up de l’Oncopole: Chronic lymphocytic leukemia: from genomics to single cell analysis - Pr Elias Campo
2022-06-17 13:00 - 14:00 | Amphithéâtre IUCT-O (& retransmission Starleaf)
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Conférence Pr Oreste Acuto : T-cell antigen receptor triggering mechanism: enigma solved?
2022-06-24 11:00 - 12:00 | Amphithéâtre IUCT-O (& retransmission Starleaf)
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Conférence Pr Frances Balkwill : Targeting the tumour microenvironment of high-grade serous ovarian cancer
2022-07-01 11:00 - 12:00 | Salle Cazaux + Visio Teams

Présentations projets lauréats AAP Translational research @IUCT-O
2022-07-07 | Amphithéâtre IUCT-O
Retrouvez tous les descriptifs des projets ici.
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Conférence Dr Frederic Saltel : Multitasking discoidin domain receptors in Tumor Microenvironment remodeling.
2022-07-08 14:30 - 15:30 | Amphithéâtre IUCT-O

Conférence Dr Marie-Laure Arcangeli : Characterization of molecular mechanisms regulating quiescence and self-renewal potential of hematopoietic stem cells.
2022-07-29 11:00 - 12:00 | Salle Cazaux + Visio Teams

Conférence : Identity theft by Natural Killers: NK cells steal PD-1 from tumor cells via trogocytosis - Dr Michele Ardolino (Ottawa Hospital Research Institute)
2022-09-09 14:30 - 15:30 | Visio Teams

Conférence : Integrative single-cell multi-omics analyses to understand leukemia resistance - Dr Mathilde Poplineau (CRCM, Marseille)
2022-09-27 13:30 - 14:30 | Salle Cazaux + Visio Teams
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Evénement gratuit et réservé à la communauté médico-scientifique.

Workshop : computational analysis and multiomics in oncology
2022-10-17 09:00 - 17:30 | Amphithéâtre IUCT-O + MS Teams
Le lundi 17 octobre aura lieu une journée dédiée aux applications bioinformatiques en biologie lors d’un workshop intitulé « Computational analysis and multiomics in oncology » ; à l’amphithéâtre de l’IUCT-Oncopole (1 avenue Joliot-Curie, 31100 Toulouse). Ce workshop est ouvert à toute la communauté scientifique.
Cliquez ici pour consulter le programme.
On monday, october 17, a day dedicated to bioinformatics applications in biology will take place during a workshop entitled « Computational analysis and multiomics in oncology »; at the IUCT-Oncopole auditorium (1 avenue Joliot-Curie, 31100 Toulouse). This workshop is open to the whole scientific community.
Click here to consult the programme

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Précision : en visio cela sera de la diffusion seulement, pas d’interaction possible à cause de la mise à jour du système de l’amphi qui n’est pas encore faite. Donc le présentiel reste à privilégier pour l’interaction.

Conférence Dr Nicolas Fraunhoffer : Multiomics integration unravels new therapeutic targets and pathobiological mechanisms in pancreatic cancer
2022-10-28 11:00 - 12:00 | Salle Cazaux + Visio Teams

Soutenance de thèse : Nathan Guiraud (équipe METAML)
2022-12-06 14:00 - 17:00 | Amphithéâtre IUCT-O + MS Teams
Soutenance de thèse de Nathan Guiraud Phd équipe METAML – Les cellules souches leucémiques : De l’origine des leucémies aigües myéloïdes à la prochaine révolution thérapeutique
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Conférence : Building a barrier to replication fork degradation with Okazaki fragment, Dr Sarah Lambert (Institut Curie)
2023-01-13 11:00 - 12:00 | Salle Cazaux + Visio Teams

Conférence : Lessons from the melanoma ecosystem, Pr Florian Rambow
2023-02-03 11:00 - 12:00 | Salle Cazaux + Visio Teams

Insights into the disruption of gene regulatory programs in cancers. Présentée par le Dr Anthony Mathelier (Molecular Medicine Norway Center, Oslo)
2023-03-10 11:00 - 12:00 | Salle Cazaux + Visio Teams
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Conférence CRCT - Epithelial memory of inflammation can be by-passed through Vps34 inactivation to limit cancer initiation. Présenté par Dr Julie Guillermet-Guibert (équipe SigDyn)
2023-03-17 11:00 - 12:00 | Salle Cazaux + Visio Teams
Conférence CRCT -Epithelial memory of inflammation can be by-passed through Vps34 inactivation to limit cancer initiation. Présenté par Dr Julie Guillermet-Guibert (équipe SigDyn)

Salle Cazaux + visio Teams
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Conférence : Different modelling strategies to suggest personalized treatments to cancer patients. Présentée par Dr Laurence Calzone, Institut Curie
2023-03-21 10:00 - 11:00 | Salle Cazaux + Visio Teams

Oncogenic pathways in cancer workshop
2023-03-31
Découvrez ici les abstracts de tous les intervenants.
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Conférence | Comment l'environnement social et les déterminants sociaux influencent le risque de cancer, sa prise en charge et son évolution | Dr Sébastien Lamy (CERPOP/IUCT)
2023-04-21 11:00 - 12:00 | Salle Cazaux + Visio Teams

Workshop axe 2 "RNA & cancer"
2023-05-12 | Amphithéâtre IUCT-O

Conférence | Understanding and predicting the role of the immune microenvironment in lung adenocarcinoma | Dr Michaël Kammer
2023-06-02 11:00 - 12:00 | Salle Cazaux + Visio Teams
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Conférence | Metabolic plasticity in ovarian cancer: a new therapeutic opportunity? | Pr Francesc Viñals
2023-06-09 11:00 - 12:00 | Salle Cazaux + Visio Teams

Conférence | Multimodal data integration for genetic diseases | Dr Anaïs Baudot
2023-06-16 11:00 - 12:00 | Salle Cazaux + Visio Teams

Conférence | Multiscale in silico modeling of life | Dr David Simoncini et Dr Sylvain Cussat-Blanc
2023-06-23 11:00 - 12:00 | Salle Cazaux + Visio Teams
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Conférence | Self-organizing principles driving tumor stemness and hierarchy | Carlos Pérez-González (Institut Curie)
2023-06-28 13:30 - 14:30 | Salle Cazaux + Visio Teams
Colorectal tumors are heterogeneous and hierarchical. Tumor growth relies on the proliferation of cancer stem cells, which constantly produce non-proliferative differentiated cells that eventually die. Despite this hierarchy, treatments targeting cancer stem cells often fail at eradicating the tumor, because the remaining cancer cells dedifferentiate to replenish the stem cell pool. It is thus crucial to understand which factors compose the tumor stem cell niche to induce cancer stemness. While most research focuses on niche factors produced by the stroma, we studied the appearance of stem cells in tumor organoids cultured in the absence of niche factors. In these minimal conditions, stem cells spontaneously appear at the center of the organoid after 3 days in culture. Physical confinement of the organoid boosts the appearance of stem cells, showing that stemness can be mechanically induced by cell crowding. Furthermore, while small organoids mostly contain cancer stem cells after 5 days of culture, large organoids position the stem cell niche at the organoid edge and develop a differentiated area in the center. These organoids establish a functional hierarchy: stem cells proliferate at the edge, migrate towards the organoid center, differentiate, and die. This spatial distribution of cell types and functions is strikingly similar to that observed in real tumors. Our results show that cancer cells have an intrinsic ability to generate a stem cell niche in the absence of external signals and that there is a critical size to establish a functional hierarchy. Further experiments will reveal the molecular mechanisms governing these self-organizing principles, as well as their contribution to tumor progression.
References:
Pérez-González C*, Ceada G* et al. Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration. Nat Cell Biol 23, 745–757 (2021).
Barbazan J*, Pérez-González C* et al. Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction. bioRxiv 2021.04.05.438443 (2021).
Pérez-González C*, Alert R* et al. Active wetting of epithelial tissues. Nat. Phys. 15, 79–88 (2019).

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