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X-WR-CALNAME:Centre de Recherches en Cancérologie de Toulouse
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260403T110000
DTEND;TZID=Europe/Paris:20260403T120000
DTSTAMP:20260408T040306
CREATED:20260325T131636Z
LAST-MODIFIED:20260330T123321Z
UID:63663-1775214000-1775217600@www.crct-inserm.fr
SUMMARY:Conférence | Clément Cazorla\, Pôle Technologique
DESCRIPTION:Pour suivre la conférence à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-clement/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2026/03/post-Conf-Clement-Cazorla.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260327T110000
DTEND;TZID=Europe/Paris:20260327T120000
DTSTAMP:20260408T040306
CREATED:20260226T134140Z
LAST-MODIFIED:20260319T151919Z
UID:63581-1774609200-1774612800@www.crct-inserm.fr
SUMMARY:Conférence | From the clinic to the bench\, and back to the clinic: applications of clinical pharmacogenetics in breast cancer\, Maud Maillard - équipe DIAD
DESCRIPTION:Conférence | From the clinic to the bench\, and back to the clinic: applications of clinical pharmacogenetics in breast cancer\, Maud Maillard – équipe DIAD
URL:https://www.crct-inserm.fr/evenement/conference-equipe-diad/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/jpeg:https://www.crct-inserm.fr/wp-content/uploads/2024/11/conference.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260325T110000
DTEND;TZID=Europe/Paris:20260325T120000
DTSTAMP:20260408T040306
CREATED:20260226T133708Z
LAST-MODIFIED:20260302T100751Z
UID:63574-1774436400-1774440000@www.crct-inserm.fr
SUMMARY:Conférence | Marco Ruscone\, Barcelona Supercomputing Center
DESCRIPTION:Multiscale Modeling of Biological Systems: Integrating Metabolism\, ECM Dynamics\, and\nAI-Driven Workflows within the PhysiCell Framework \nMultiscale models provide a powerful means of studying complex biological processes across multiple spatial and temporal scales. They capture both intracellular events\, such as signaling and metabolism\, and extracellular interactions where cells communicate and coordinate. By revealing how genetic or environmental deregulation affects diseas progression\, these models can suggest strategies to restore healthy phenotypes. In this talk\, I will present recent updates to the PhysiCell ecosystem developed at the Barcelona Supercomputing Center (BSC). I will introduce PhysiCelldFBA\, an extension that\nintegrates dynamic flux balance analysis to simulate metabolism within individual agents\, and PhysiMESS\, a plugin designed to simulate the complex 3D architecture of the extracellular matrix fibers. To demonstrate the versatility of these tools\, I will showcase several use cases\, ranging from metabolic switching in E. coli to large-scale cancer growth models.\nFinally\, I will discuss a novel integration of mechanistic modeling and artificial intelligence: the development of Model Context Protocol (MCP) servers. These servers transform Large\nLanguage Models (LLMs) into specialized modeling assistants\, enabling them to leverage tools such as NeKO for Boolean network construction\, maBoSS for stochastic simulations\, and PhysiBoSS for multiscale modeling. This framework represents a significant step toward automating the design and execution of complex biological simulations. \nMarco Ruscone is a postdoctoral researcher in the Life Science Department\, coordinated by Professor Alfonso Valencia\, at the Barcelona Supercomputing Center (BSC). He began his academic career in Turin\, Italy\, earning a bachelor’s degree in Physics and a master’s degree in Physics of Complex Systems for Biology from the Università degli Studi di Torino. He completed his PhD in Computational Biology at the Institut Curie in Paris\, under the mentorship of Dr. Laurence Calzone\, Dr. Andrei Zinovyev\, and Dr. Vincent Noël. His research centers on developing multiscale models for cancer\, employing a hybrid approach that combines agent-based modeling techniques\, stochastic simulations on Boolean networks and AI automation. \nPour suivre la conférence en direct\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-marco-ruscone-barcelona-supercomputing-center/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2026/02/Conf-Marco-Ruscone.png
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260320
DTEND;VALUE=DATE:20260321
DTSTAMP:20260408T040306
CREATED:20260226T133206Z
LAST-MODIFIED:20260302T142533Z
UID:63568-1773964800-1774051199@www.crct-inserm.fr
SUMMARY:Workshop Hematology & Immunology
DESCRIPTION:En savoir plus
URL:https://www.crct-inserm.fr/evenement/workshop-hematology-immunology/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2026/02/Capture-decran-2026-03-02-a-15.01.45-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260313T110000
DTEND;TZID=Europe/Paris:20260313T120000
DTSTAMP:20260408T040306
CREATED:20260226T131438Z
LAST-MODIFIED:20260226T131842Z
UID:63558-1773399600-1773403200@www.crct-inserm.fr
SUMMARY:Conférence | Mary Poupot\, équipe NetB(IO)²
DESCRIPTION:Pour suivre la conférence en direct\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-mary-poupot-equipe-netbio%c2%b2/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2026/02/Conf-Mary-Poupot-13-mars.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260305T103000
DTEND;TZID=Europe/Paris:20260305T120000
DTSTAMP:20260408T040306
CREATED:20260226T105515Z
LAST-MODIFIED:20260302T093205Z
UID:63546-1772706600-1772712000@www.crct-inserm.fr
SUMMARY:Mini symposium
DESCRIPTION:Crosstalks between Death Receptor signalling and the endoplasmic reticulum stress response in cancer\nInteractions entre la signalisation des récepteurs de mort et la réponse au stress du réticulum endoplasmique dans le cancer. \nElodie Lafont \nThroughout tumour development\, cancer cells are subjected to both intrinsic and extrinsic stresses with which they must cope to survive and proliferate. Adapted tumour cells survive this selection pressure through the activation of specific signalling pathways. Amongst those are the signalling engaged by the death receptors (DR) and the unfolded protein response (UPR)\, an adaptive response to endoplasmic reticulum stress. In this talk we will present several aspects linking the UPR\, and in particular its sensor IRE1\, and DR signalling in glioblastoma and triple-negative breast cancer cells\, and their functional consequences on cell fate. \nKeywords: Death receptors\, Unfolded protein response\, CD95\, TRAIL-R1/2\, IRE1\, Triple-negative breast cancer\, Cell death \n  \nInteraction CD27-CD70 : un nouveau mécanisme d’évasion tumorale \nEric Tartour \nLes molécules de costimulation sont connues pour favoriser la stimulation et la prolifération des lymphocytes T\, en synergie avec le récepteur T. Parmi ces molécules\, CD27\, exprimé par les lymphocytes T\, interagit avec son ligand CD70\, exprimé par les cellules présentatrices d’antigènes (lymphocytes T). À partir d’une analyse de données publiques (TCGA)\, nous avons d’abord observé que les cellules tumorales dérivées de cancers du rein exprimaient de forts niveaux d’ARN codant pour le CD70\, ce qui nous a paru paradoxal étant donné la fonction connue de cette molécule. Nous avons ensuite confirmé au niveau protéique qu’une interaction existait bien entre la molécule CD70 et la molécule CD27 exprimée par les lymphocytes T dans le microenvironnement des tumeurs du rein. Ces lymphocytes T étaient dysfonctionnels et exprimaient de nombreux marqueurs associés à l’apoptose (Benhamouda N. et al.\, Clin Cancer Res.\, 2022). De façon intéressante\, l’interaction entre CD27 et CD70 conduit au clivage de la molécule CD27\, libérant ainsi sa portion extracellulaire\, que l’on peut retrouver dans le plasma. Nous avons observé une corrélation entre le nombre d’interactions entre CD27 et CD70 dans l’environnement tumoral et les concentrations plasmatiques de CD27 soluble. Nous avons émis l’hypothèse que ces concentrations de CD27s pouvaient refléter un état dysfonctionnel des lymphocytes T\, secondaire à une interaction chronique entre CD27-CD70\,  qui seraient résistants à la réactivation par une immunothérapie anti-PD-1. Cette hypothèse a été validée en montrant que les concentrations de CD27s sont associées à la résistance au traitement par anti-PD-1 chez des patients atteints d’un cancer du rein métastatique. Nous avons étendu ces résultats à la dysfonction des lymphocytes T exprimant le CD27 et au caractère prédictif des concentrations de CD27s chez des patients atteints de mélanomes métastatiques (Sam I et al.\, Embo Mol Med\, 2025 ; Sam I.\, Clin Cancer Res\, 2025). \nMots clefs: Immunothérapie du cancer\, mécanisme d’évasion tumorale\, Biomarqueur\, Axe CD27-CD70. \n  \n 
URL:https://www.crct-inserm.fr/evenement/mini-symposium-2/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2026/02/Mini-symposium-5-mars-26.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260225T100000
DTEND;TZID=Europe/Paris:20260225T113000
DTSTAMP:20260408T040306
CREATED:20260126T142950Z
LAST-MODIFIED:20260206T155006Z
UID:63274-1772013600-1772019000@www.crct-inserm.fr
SUMMARY:Conférence Foundation Models for Oncology - Pr Jonas Teuwen\, NKI
DESCRIPTION:Biosketch: \nJonas Teuwen is the Group Leader of the AI for Oncology Lab at the Netherlands Cancer Institute. He was previously a tenure-track assistant professor at the Radboud University Medical Center. Previous he was a postdoc in medical image analysis at the same institute. He obtained his PhD in 2016 in Mathematics and Physics from the Delft University of Technology.\nHis interests are in the application and development of novel AI methodologies to benefit the diagnosis and treatment of cancer. \n————————————————————— \nPour suivre la conférence en direct\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-pr-jonas-teuwen-nki/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2026/01/post-Conf-J.Teuwen.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260130T110000
DTEND;TZID=Europe/Paris:20260130T120000
DTSTAMP:20260408T040306
CREATED:20260102T104423Z
LAST-MODIFIED:20260105T103002Z
UID:63132-1769770800-1769774400@www.crct-inserm.fr
SUMMARY:Conférence | Integrating biochemical cues of the extracellular matrix with cell metabolism in metastatic pancreatic ductal adenocarcinoma - Georgios Efthymiou\, CRCM
DESCRIPTION:Abstract :\nPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal cancer with worryingly increasing incidence in developed countries. Key aspects that underline PDAC aggressiveness are the pronounced desmoplasia and the metabolic adaptability\, features that are commonly found in the primary and the metastatic site. Desmoplasia refers to the enhanced production and deposition of extracellular matrix (ECM) components\, which results to dramatic alterations in tissue architecture. Within this metabolically challenging tumor microenvironment (TME)\, tumor cells promote metabolic adaptations to maintain tumorigenic properties\, including proliferation\, chemoresistance\, and metastatic dissemination and expansion. \nIn this talk I will illustrate examples of ECM-driven tumorigenic properties\, such as the capacity of cells to alleviate the effects of chemotherapy by promoting DNA repair mechanisms. I will also present ECM-driven metabolic adaptations in the primary PDAC that contribute to chemoresistance. More specifically\, I will focus on the nucleotide imbalance observed in PDAC\, and reported in other solid cancers\, and describe the role of guanylates as mediators of chemoresistance. Relevant strategies to improve responses to therapy will be discussed. \nFinally\, I will share preliminary results on the emerging notion of the liver pre-metastatic niche (PMN) in PDAC. The PMN comprises ECM and metabolic alterations that favor metastatic cell seeding and subsequent metastatic expansion. The exploration of these alterations may help slow down or halt metastatic dissemination and increase the number of eligible patients for surgical resection. \nPour suivre la conférence à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-integrating-biochemical-cues-of-the-extracellular-matrix-with-cell-metabolism-in-metastatic-pancreatic-ductal-adenocarcinoma-george-efthymiou-crcm/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/12/Conf-G.-George-Efthymiou.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260123T110000
DTEND;TZID=Europe/Paris:20260123T120000
DTSTAMP:20260408T040306
CREATED:20251217T142841Z
LAST-MODIFIED:20251217T142841Z
UID:63114-1769166000-1769169600@www.crct-inserm.fr
SUMMARY:Conférence | Mécanismes immunitaires gouvernant l’efficacité thérapeutique dans le myélome multiple -  Ludovic Martinet\, équipe Genim
DESCRIPTION:Pour suivre la conférence en direct\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-mecanismes-immunitaires-gouvernant-lefficacite-therapeutique-dans-le-myelome-multiple-ludovic-martinet-equipe-genim/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/12/AS-Martinet.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260115T093000
DTEND;TZID=Europe/Paris:20260115T120000
DTSTAMP:20260408T040306
CREATED:20251126T090403Z
LAST-MODIFIED:20260106T155153Z
UID:62900-1768469400-1768478400@www.crct-inserm.fr
SUMMARY:Séminaire technologique Société Visiopharm
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/seminaire-technologique-societe-visiopharm/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/11/seminaire-visiopharm.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260109T110000
DTEND;TZID=Europe/Paris:20260109T120000
DTSTAMP:20260408T040306
CREATED:20251217T141250Z
LAST-MODIFIED:20251217T141250Z
UID:63109-1767956400-1767960000@www.crct-inserm.fr
SUMMARY:Conférence | Mapping Cancer Complexity: A Multi-Omics Journey from Global Public Datasets to Pediatric Precision Medicine - Antonio Colaprico\, Institut Curie
DESCRIPTION:Pour suivre la conférence en direct\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-mapping-cancer-complexity-a-multi-omics-journey-from-global-public-datasets-to-pediatric-precision-medicine-antonio-colaprico-institut-curie/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/12/AS-Colaprico.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260108T110000
DTEND;TZID=Europe/Paris:20260108T123000
DTSTAMP:20260408T040306
CREATED:20251209T152124Z
LAST-MODIFIED:20260107T090920Z
UID:63078-1767870000-1767875400@www.crct-inserm.fr
SUMMARY:Séminaire technologique Ultima Genomics
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/seminaire-technologique-ultima-genomics/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/12/semianire-ultima-genomics.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251230T110000
DTEND;TZID=Europe/Paris:20251230T120000
DTSTAMP:20260408T040306
CREATED:20251219T153325Z
LAST-MODIFIED:20251219T153325Z
UID:63123-1767092400-1767096000@www.crct-inserm.fr
SUMMARY:Conférence : Integrating biochemical cues of the extracellular matrix with cell metabolism in metastatic pancreatic ductal adenocarcinoma - George Efthymiou\, PhD
DESCRIPTION:Integrating biochemical cues of the extracellular matrix with cell metabolism in metastatic pancreatic ductal adenocarcinoma \nSynopsis \nPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal cancer with worryingly increasing incidence in developed countries. Key aspects that underline PDAC aggressiveness are the pronounced desmoplasia and the metabolic adaptability\, features that are commonly found in the primary and the metastatic site. Desmoplasia refers to the enhanced production and deposition of extracellular matrix (ECM) components\, which results to dramatic alterations in tissue architecture. Within this metabolically challenging tumor microenvironment (TME)\, tumor cells promote metabolic adaptations to maintain tumorigenic properties\, including proliferation\, chemoresistance\, and metastatic dissemination and expansion. \nIn this talk I will illustrate examples of ECM-driven tumorigenic properties\, such as the capacity of cells to alleviate the effects of chemotherapy by promoting DNA repair mechanisms. I will also present ECM-driven metabolic adaptations in the primary PDAC that contribute to chemoresistance. More specifically\, I will focus on the nucleotide imbalance observed in PDAC\, and reported in other solid cancers\, and describe the role of guanylates as mediators of chemoresistance. Relevant strategies to improve responses to therapy will be discussed. \nFinally\, I will share preliminary results on the emerging notion of the liver pre-metastatic niche (PMN) in PDAC. The PMN comprises ECM and metabolic alterations that favor metastatic cell seeding and subsequent metastatic expansion. The exploration of these alterations may help slow down or halt metastatic dissemination and increase the number of eligible patients for surgical resection.
URL:https://www.crct-inserm.fr/evenement/conference-integrating-biochemical-cues-of-the-extracellular-matrix-with-cell-metabolism-in-metastatic-pancreatic-ductal-adenocarcinoma-george-efthymiou-phd/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/12/Conf-G.-George-Efthymiou.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251218T093000
DTEND;TZID=Europe/Paris:20251218T113000
DTSTAMP:20260408T040306
CREATED:20251126T095431Z
LAST-MODIFIED:20251208T135350Z
UID:62911-1766050200-1766057400@www.crct-inserm.fr
SUMMARY:Workshop : Signal\, Metabolize\, Dysfunction: Mechanisms in Blood & Vascular Disease
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/mini-symposium/
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/jpeg:https://www.crct-inserm.fr/wp-content/uploads/2025/11/Workshop_2025_12_18_RD-2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251212T133000
DTEND;TZID=Europe/Paris:20251212T170000
DTSTAMP:20260408T040306
CREATED:20251126T083806Z
LAST-MODIFIED:20251126T083806Z
UID:62898-1765546200-1765558800@www.crct-inserm.fr
SUMMARY:Soutenance de thèse de Karina Cancino - Pôle Techno
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-de-karina-cancino-pole-techno/
LOCATION:Salle Cazaux
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2023/07/these5.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251208T110000
DTEND;TZID=Europe/Paris:20251208T120000
DTSTAMP:20260408T040306
CREATED:20251125T152853Z
LAST-MODIFIED:20251201T095800Z
UID:62891-1765191600-1765195200@www.crct-inserm.fr
SUMMARY:Conférence Dr Robert Ballotti - Identifying the Epigenetic Players Involved in Melanoma Resistance to Targeted Therapies and to the Immune System.
DESCRIPTION:Identifying the Epigenetic Players Involved in Melanoma Resistance to Targeted Therapies and to the Immune System. \nSince 2011-2012 and the use of targeted therapies and immunotherapies in the treatment of metastatic melanoma\, progress in terms of patient survival is evident\, with an increase in median survival from less than a year to over 5 years with immunotherapies. However\, almost 50% of patients are in therapeutic dead-end\, due to frequent resistance to treatment.  The main challenge today is to decipher the mechanisms of resistance to targeted therapies (TC) or immunotherapies (IT) and propose therapeutic approaches to block or reverse these processes. \nIn 2018\, we demonstrated that increased cellular levels of NAD+ render melanoma cells resistant to targeted therapies. This resistance is associated with dedifferentiation and specific epigenetic modifications. Focusing on these non-genetic resistance patterns associated with dedifferentiation\, we have identified epigenetic players whose inhibition resensitizes melanoma cells to TCs and increases their immunogenicity. \nOur data identify epigenetic players involved in the acquisition of resistance to TC and in the alteration of the immune response in melanoma cells. This results lay the foundations for new therapeutic strategies targeting epigenetic alterations to overcome resistance. \nPour suivre la conférence à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-dr-robert-ballotti-identifying-the-epigenetic-players-involved-in-melanoma-resistance-to-targeted-therapies-and-to-the-immune-system/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/11/conf-robert-ballotti.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251204T100000
DTEND;TZID=Europe/Paris:20251204T120000
DTSTAMP:20260408T040306
CREATED:20251106T141053Z
LAST-MODIFIED:20251201T095446Z
UID:62687-1764842400-1764849600@www.crct-inserm.fr
SUMMARY:Séminaire technologique | BIABooster - Adelis
DESCRIPTION:Pour suivre le séminaire à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/seminaire-technologique-biabooster/
LOCATION:Salle Cazaux + Espace détente 1er étage
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/11/seminaire-Adelis.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251127T133000
DTEND;TZID=Europe/Paris:20251127T170000
DTSTAMP:20260408T040306
CREATED:20251015T141227Z
LAST-MODIFIED:20251127T140010Z
UID:62316-1764250200-1764262800@www.crct-inserm.fr
SUMMARY:Soutenance de thèse de Célia Ramade\, équipe T2i
DESCRIPTION:Soutenance de thèse de Célia Ramade\, équipe T2i
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-de-celia-ramade-equipe-t2i/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2023/07/these5.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251127T093000
DTEND;TZID=Europe/Paris:20251127T120000
DTSTAMP:20260408T040306
CREATED:20251015T140719Z
LAST-MODIFIED:20251117T093956Z
UID:62311-1764235800-1764244800@www.crct-inserm.fr
SUMMARY:Mini-symposium sur l'onco-immunologie
DESCRIPTION:Sans inscription.
URL:https://www.crct-inserm.fr/evenement/mini-symposium-sur-lonco-immunologie/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/10/Capture-decran-2025-10-15-a-09.52.25.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251121T110000
DTEND;TZID=Europe/Paris:20251121T120000
DTSTAMP:20260408T040306
CREATED:20251015T140017Z
LAST-MODIFIED:20251030T131949Z
UID:62307-1763722800-1763726400@www.crct-inserm.fr
SUMMARY:Conférence Lorenzo Scipioni
DESCRIPTION:Pour suivre la conférence à distance\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-lorenzo-scipioni/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/10/L.Scipioni-21.11.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251114T134500
DTEND;TZID=Europe/Paris:20251114T170000
DTSTAMP:20260408T040306
CREATED:20251015T134202Z
LAST-MODIFIED:20251015T134202Z
UID:62303-1763127900-1763139600@www.crct-inserm.fr
SUMMARY:Soutenance de thèse de Camille Guyon\, équipe SigDyn
DESCRIPTION:Soutenance de thèse de Camille Guyon\, équipe SigDyn\nPlasticité du pancréas exocrine\, cancérogenèse et implication de la PI3Kinase VPS34
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-de-camille-guyon-equipe-sigdyn/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2023/07/these5.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251114T110000
DTEND;TZID=Europe/Paris:20251114T120000
DTSTAMP:20260408T040306
CREATED:20251015T133657Z
LAST-MODIFIED:20251106T133933Z
UID:62301-1763118000-1763121600@www.crct-inserm.fr
SUMMARY:Conférence de Olivier Meurette - CRCL
DESCRIPTION:Kremen1 induces SEC24C/ATG9A-dependent cell death in cancer cells. \nKremen1 is a receptor for Dickkopf (DKK) ligands which are WNT inhibitors. It has also been reported to induce cancer cell death in the absence of its ligand\, DKK1; however\, the precise mechanism underlying Kremen1-mediated cell death remains unclear. Our observations indicate that Kremen1 induces a form of cell death characterized by non-apoptotic features\, accompanied by the accumulation of numerous vesicles and autophagosomes. Through biotin-based proximity labeling for protein-protein interaction analysis\, we identified SEC24C—a component of the COP-II complex—as a critical effector in Kremen1-induced autophagy and cell death. Furthermore\, our data demonstrate that Kremen1 localizes in proximity to SEC24C and ATG9A following vesicular trafficking and promotes the interaction of SEC24C with ATG8\, ERGIC\, and ATG9A. This network of interactions may underlie the increased formation of autophagosomes and vacuoles that culminate in cell death. Given that DKK1 is frequently upregulated in cancer and correlates with poor prognosis\, reactivating the Kremen1-dependent cell death pathway may represent a promising therapeutic strategy. Ongoing studies are comparing this pathway to other cell death modalities to evaluate its potential utility in cancer therapy. \nPour suivre la conférence en direct\, cliquez ici.
URL:https://www.crct-inserm.fr/evenement/conference-autophagic-cell-death-mechanical-constraints-and-signalling-pathways-in-cancer/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/10/Olivier-Meurette-1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251113T100000
DTEND;TZID=Europe/Paris:20251113T123000
DTSTAMP:20260408T040306
CREATED:20251015T131830Z
LAST-MODIFIED:20251023T124923Z
UID:62294-1763028000-1763037000@www.crct-inserm.fr
SUMMARY:Séminaire technologique |  Incucyte CX3-CellCelector
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/seminaire-technologique-incucyte-cx3-cellcelector/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/10/seminaire-sartorius.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251029T140000
DTEND;TZID=Europe/Paris:20251029T170000
DTSTAMP:20260408T040306
CREATED:20250925T083724Z
LAST-MODIFIED:20251027T083210Z
UID:62119-1761746400-1761757200@www.crct-inserm.fr
SUMMARY:Rôle de l’ubiquitine ligase TRIP12 dans la régulation de la réponse aux cassures double-brin de l’ADN: interaction compétitive avec MDC1 et développement d’outils quantitatifs de colocalisation - Damien Varry\, équipe ImPact
DESCRIPTION:Rôle de l’ubiquitine ligase TRIP12 dans la régulation de la réponse aux cassures double-brin de l’ADN: interaction compétitive avec MDC1 et développement d’outils quantitatifs de colocalisation. \nPrésenté par Damien Varry\, équipe imPact
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-damien-varry-equipe-impact/
LOCATION:Salle Cazaux
CATEGORIES:Évènement
ATTACH;FMTTYPE=image/jpeg:https://www.crct-inserm.fr/wp-content/uploads/2024/12/visuels-agenda.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251029T110000
DTEND;TZID=Europe/Paris:20251029T120000
DTSTAMP:20260408T040306
CREATED:20250925T083355Z
LAST-MODIFIED:20250925T084354Z
UID:62116-1761735600-1761739200@www.crct-inserm.fr
SUMMARY:Dr Philippe Soubeyran\, CRCM
DESCRIPTION:L’ubiquitination est une modification post-traductionnelle majeure impliquée dans la régulation de la plupart des processus cellulaires. Bien qu’elle soit surtout connue pour promouvoir la dégradation des protéines par le protéasome\, elle joue également un rôle clé dans la régulation des fonctions\, des interactions et de la localisation des protéines. Par conséquent\, des altérations de l’ubiquitination sont impliquées dans la plupart des maladies\, y compris le cancer.\nPour explorer le rôle de l’ubiquitination dans le cancer du pancréas\, nous avons généré les profils d’ubiquitination de 60 modèles de xénogreffes dérivés de patients (PDX) issus d’adénocarcinomes pancréatiques (PDAC). Parmi les résultats obtenus grâce à des analyses bio-informatiques\, nous avons identifié 38 profils d’ubiquitination associés à la résistance aux principaux traitements chimio-thérapeutiques du PDAC\, la gemcitabine et aux principaux composants du protocole FOLFIRINOX\, à savoir le 5-FU\, l’oxaliplatine et l’irinotécan.\nDans un premier temps\, ces profils d’ubiquitination pourraient servir de marqueurs théranostiques\, capables de prédire l’efficacité de chaque traitement. De plus\, en raison de leurs multiples fonctions régulatrices\, ces ubiquitinations pourraient également être impliquées dans des mécanismes de résistance\, notamment lorsqu’elles modifient des protéines oncogéniques\, suppressives de tumeurs ou des régulateurs biologiques majeurs.\nAfin de valider ou d’invalider l’efficacité de ces ubiquitinations comme marqueurs théranostiques\, nous utilisons la technique de proximity ligation assay (PLA) pour détecter et quantifier le niveau d’ubiquitination de chaque cible sur un tissue micro array (TMA) de 20 PDX présentant divers scores de résistance. Cette approche nous a permis de confirmer l’utilité de certaines de ces protéines ubiquitinées comme marqueurs prédictifs de résistance.\nEn parallèle\, nous explorons également le potentiel de ces ubiquitinations comme nouvelles cibles moléculaires qui permettraient de restaurer la sensibilité des cellules cancéreuses pancréatiques aux traitements standards. Nous créons des protéines déficientes en ubiquitination\, par mutagénèse dirigée\, que nous comparons aux protéines sauvages (ubiquitinées). Nous avons mis en évidence que certaines de ces ubiquitinations jouent effectivement un rôle dans les mécanismes de résistance. Elles pourraient donc être utilisées à l’avenir comme cibles co-thérapeutiques\, améliorant l’efficacité du traitement. \nSuivre la conférence en direct : cliquez ici \n\nAbstract:\nUbiquitination is a major post-translational modification involved in the regulation of most cellular processes. It is well-known for promoting protein degradation by the proteasome but it is also involved in the regulation of proteins’ functions\, interactions\, localization. Consequently\, alterations of ubiquitination are involved in most diseases\, including cancer. To explore the roles of ubiquitination in pancreatic cancer\, we have generated the ubiquitination profiles from 60 PDXs derived from pancreatic ductal adenocarcinomas (PDAC). Among the results revealed by bioinformatic analyses of these data\, we identified 38 ubiquitination profiles associated with resistance to the main chemotherapy treatment for PDAC\, gemcitabine\, as well as to the main components of the Folfirinox protocol\, namely 5-FU\, oxaliplatin\, and irinotecan. These ubiquitination profiles could first serve as theranostic markers\, predicting the efficacy of each treatments. Moreover\, because of its multiple regulatory functions\, these ubiquitinations could also be involve in a resistance mechanism. This is especially true when ubiquitin is conjugated to oncogenic or tumor-suppressor proteins or main biological regulators.\nIn order to validate\, or invalidate\, the efficiency of these ubiquitinations as theranostic markers\, we use proximity ligation assay (PLA) to detect and quantify the ubiquitination level of each target on a tissue micro array (TMA) of 20 PDXs with various resistance scores. This approach enabled us to confirm the usefulness of some of these ubiquitinated proteins as predictive markers of resistance. In parallel\, we also explore the potential of these ubiquitinations as new molecular targets that could be used to restore PDAC sensitivity to standard treatments. We create proteins deficient in ubiquitination\, through site-directed mutagenesis\, which we compare to wild-type (ubiquitinated) proteins. We have shown that some of these ubiquitinations do indeed play a role in resistance mechanisms. They could therefore be used in the future as co-therapeutic targets\, improving the efficacy of the treatment. \n  \nEvénement soutenu par la SFRB2S
URL:https://www.crct-inserm.fr/evenement/dr-philippe-soubeyran-crcm/
LOCATION:Salle Cazaux
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/09/Conf-Philippe-Soubeyran.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251024T134500
DTEND;TZID=Europe/Paris:20251024T170000
DTSTAMP:20260408T040306
CREATED:20250925T081008Z
LAST-MODIFIED:20250929T111105Z
UID:62114-1761313500-1761325200@www.crct-inserm.fr
SUMMARY:Soutenance de thèse Sanzhar Aitbay\, équipe SigDYN
DESCRIPTION:Titre : Stress biomécanique & son impact sur la signalisation oncogénique des PI3Ks.
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-sanzhar-aitbay-equipe-sigdyn/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Évènement
ATTACH;FMTTYPE=image/jpeg:https://www.crct-inserm.fr/wp-content/uploads/2024/12/visuels-agenda.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251024T093000
DTEND;TZID=Europe/Paris:20251024T120000
DTSTAMP:20260408T040306
CREATED:20250925T080509Z
LAST-MODIFIED:20250929T084458Z
UID:62110-1761298200-1761307200@www.crct-inserm.fr
SUMMARY:Workshop
DESCRIPTION:
URL:https://www.crct-inserm.fr/evenement/cell-state-dynamics-mechanobiology-in-cancer-clinical-translational-basic-views/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/09/to-Post-affiche-Mechanobiology-and-PDAC-workshop_JG_SA_RDfinal-2.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251022T133000
DTEND;TZID=Europe/Paris:20251022T170000
DTSTAMP:20260408T040306
CREATED:20251002T092156Z
LAST-MODIFIED:20251015T124752Z
UID:62218-1761139800-1761152400@www.crct-inserm.fr
SUMMARY:Soutenance de thèse Océane Dainese-Marque\, équipe Melasphinx
DESCRIPTION:Soutenance de thèse : Etude des effets paracrines de la Sphingosine-1-Phosphate sur le phénotype des cellules de mélanome.\nOcéane Dainese-Marque\, équipe Melasphinx
URL:https://www.crct-inserm.fr/evenement/soutenance-de-these-oceane-dainese-marque-equipe-melasphinx/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Évènement
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2023/07/these5.png
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251016
DTEND;VALUE=DATE:20251017
DTSTAMP:20260408T040306
CREATED:20250925T070612Z
LAST-MODIFIED:20250929T123007Z
UID:62104-1760572800-1760659199@www.crct-inserm.fr
SUMMARY:Workshop
DESCRIPTION:Informations et inscriptions ici : https://immunoncoinfo.sciencesconf.org/
URL:https://www.crct-inserm.fr/evenement/workshop-2/
LOCATION:Amphithéâtre IUCT-O
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/09/Capture-decran-2025-09-29-a-10.46.22.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251010T110000
DTEND;TZID=Europe/Paris:20251010T120000
DTSTAMP:20260408T040306
CREATED:20250925T083906Z
LAST-MODIFIED:20250926T123034Z
UID:62122-1760094000-1760097600@www.crct-inserm.fr
SUMMARY:Conférence Maha Ayyoub
DESCRIPTION:Suivre la conférence en direct : cliquez ici \n 
URL:https://www.crct-inserm.fr/evenement/conference-maha-ayyoub/
LOCATION:Salle Cazaux + Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2025/09/post-Conf.pngConf-Maha-Ayyoub.png
END:VEVENT
END:VCALENDAR