BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Centre de Recherches en Cancérologie de Toulouse - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Centre de Recherches en Cancérologie de Toulouse
X-ORIGINAL-URL:https://www.crct-inserm.fr
X-WR-CALDESC:Évènements pour Centre de Recherches en Cancérologie de Toulouse
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Europe/Paris
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20210328T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20211031T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20220327T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20221030T010000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
TZNAME:CEST
DTSTART:20230326T010000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
TZNAME:CET
DTSTART:20231029T010000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20220510T133000
DTEND;TZID=Europe/Paris:20220510T143000
DTSTAMP:20260411T005136
CREATED:20220422T125727Z
LAST-MODIFIED:20220506T091152Z
UID:49038-1652189400-1652193000@www.crct-inserm.fr
SUMMARY:Séminaire Axe 2 : Diversity in rRNA 2’Ome profiles in cancer and impact on translational regulation - Virginie Marcel\, CRCL (Lyon)
DESCRIPTION:Diversity in rRNA 2’Ome profiles in cancer and impact on translational regulation – Virginie Marcel \nCancer Research Center of Lyon\, UMR INSERM 1052 CNRS 5286\, Centre Léon Bérard\, Université Lyon 1\, Nuclear domains and pathologies team\, Lyon\, France \nWhile the ribosome was considered for over 40 years as a neutral actor of gene expression\, it now appears as a key regulator of translation through modulation of its composition\, including via chemical modifications of ribosomal RNAs (rRNAs). In cellular models\, we revealed that ribose 2’-Omethylation (2’Ome) of rRNA can be modulated in human and become a source of ribosome diversity. We reported that 2’Ome is altered during tumorigenesis and directly affects translational behavior of ribosomes toward mRNA subsets. However\, whether alteration of rRNA 2’Ome occurs in “real-life” remained to be demonstrated. Thanks to an innovative omic technology\, the RiboMETH-seq\, we made the first demonstration that rRNA 2’Ome is altered in different cancer types\, including breast cancer and glioma. It appears that variability in rRNA 2’Ome level is restricted to only a subset of positions. Moreover\, comparison of several adult tumors indicates that most of these variable sites are common to different tumor sites while few of them are specific to particular cancer type. Our data support the recent entry of the ribosome into the emerging field of epitranscriptomics. \nSelected references \n(1) Marcel et al. (2013) Cancer Cell 24\, 318-330. \n(2) Erales et al. (2017) PNAS 114\, 12934-12939. \n(3) Marcel et al. (2020) NAR Cancer 2\, 318. \n(4) Jaafar et al. (2021) Cells 10\, 1948. \nCliquez ici pour accéder à la visioconférence MS Teams.
URL:https://www.crct-inserm.fr/evenement/seminaire-axe-2-diversity-in-rrna-2ome-profiles-in-cancer-and-impact-on-translational-regulation-virginie-marcel-crcl-lyon/
LOCATION:Visio Teams
CATEGORIES:Animation scientifique
ATTACH;FMTTYPE=image/png:https://www.crct-inserm.fr/wp-content/uploads/2022/04/CRCL.png
END:VEVENT
END:VCALENDAR