Dr. Laura POILLET / Autophagy maintains tumor growth through circulating arginina

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Dr. Laura POILLET, Rutgers Cancer Institute of New Jersey, New Brunswick, USA Autophagy captures intracellular components and delivers them to lysosomes where they are degraded and recycled to sustain metabolism and to enable survival in starvation. Acute, whole-body deletion of the essential autophagy gene Atg7 in adult mice causes a systemic metabolic defect manifested by […]

Dr. Fabien JOURDAN / Methods and tools to model cellular metabolism

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Dr. Fabien JOURDAN, INRA Toxalim, Toulouse, France Metabolic modulation is a cornerstone cellular response to genetic or environmental stresses. In particular, cancerous cells can cope with key genetic mutations by using metabolic bypasses. This plasticity is going beyond central metabolism and may involve complex processes spanning several metabolic pathways. Hence, it is a key challenge […]

Séminaire technologique / Bruno PISCAGLIA, TELEMIS

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

About Bruno Piscaglia:  Bruno is one of the TELEMIS co-founders and previous research assistant at the University. He is graduated in Mathematics and is currently Chief Technology Officer at TELEMIS. About TELEMIS: TELEMIS is a spin off company of the catholic university of Louvain (UCL) in Belgium, and more specially of Prof. Benoit Macq’s the […]

Dr. Pierre FONS & Dr. Michaël ESQUERRE, EVOTEC / “Les vendredis de l’Oncopole”: introducing Evotec immuno-oncology/clinical translation expertise through EVT801: a selective VEGFR3 inhibitor proposed as single therapy and for combination with immune-checkpoint therapies (ICT)

Auditorium Claudius Regaud Institut Universitaire du cancer de Toulouse-Oncopole, 1 avenue Irène Joliot-Curie , Toulouse

Dr. Pierre FONS & Dr. Michaël ESQUERRE, EVOTEC / "Les vendredis de l'Oncopole": introducing Evotec immuno-oncology/clinical translation expertise through EVT801: a selective VEGFR3 inhibitor proposed as single therapy and for combination with immune-checkpoint therapies (ICT) Evotec is a drug discovery alliance company with mainly a European footprint. Evotec has its own R&D portfolio of projects […]

Pr. Dieter SAUR / Heterogeneity of Pancreatic Cancer – Implications for Future Therapies?

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Pr. Dieter SAUR, TUM, Munich Treatment resistance of pancreatic cancer (PDAC) depends on cancer cell intrinsic mechanisms and an immunosupressive tumor stroma that supports tumour growth. Mouse models have provided important insights into the evolution of this highly lethal tumour, but there are no models that allow secondary genetic manipulation of autochthonous tumours, the immune […]

Pr. Alex ODERMATT / Role of 11β-hydroxysteroid dehydrogenase enzymes in oxysterol and bile acid metabolism

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Pr. Alex ODERMATT, University of Basel, Switzerland 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 and type 2 are well known to control the cell- and tissue-specific interconversion of inactive and active glucocorticoids. Besides, these enzymes represent a link between glucocorticoid and oxysterol and bile acid homeostasis. Several bile acids inhibit 11β-HSDs and we recently demonstrated that 11β-HSD1 […]

Pr. Liam HOLT / Control and consequences of the physical properties of cells

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Pr. Liam HOLT, New York University, NYU Langone Health, The Helen L. and Martin S. Kimmel Center for stem cell biology The talk at a glance Tens of thousands of biochemical reactions occur simultaneously in the cell. Small molecules are channeled through metabolic pathways at blistering speed. Giant complexes assemble to orchestrate transcription and translation. […]

Dr Jérome Déjardin, IGH Montpellier – The control of transposable elements by chromatin

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Metastable epialleles are alleles variably expressed in genetically identical individuals. The nearby insertion of an endogenous retrovirus (ERV), particularly of the Intracisternal A Particle (IAP) class, is a major feature of mouse epialleles. Some IAP insertions are variably methylated between individuals and can influence neighboring gene expression providing « epigenetic » inter-individual differences. How metastable […]

Dr Antonio Maraver IRCM, Montpellier – Role of the Notch pathway in lung adenocarcinoma biology and treatment: lessons from preclinical mouse models

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

EGFR mutated lung adenocarcinoma patients treated with gefitinib and osimertinib show a therapeutic benefit limited by the appearance of secondary mutations, such as EGFRT790M and EGFRC797S. It is generally assumed that these secondary mutations render EGFR completely unresponsive to the inhibitors, but contrary to this, we uncovered here that gefitinib and osimertinib increased STAT3 phosphorylation […]

Pr Roland Liblau CPTP, Toulouse – Immune checkpoint blockade, neuroinflammation and paraneoplastic neurological disease

Salle C. Cazaux, CRCT 2 Avenue Hubert Curien , Toulouse

Paraneoplastic neurologic disorders (PND) are immune-mediated neurological diseases that develop in the setting of malignancy. The target onconeural antigens are expressed physiologically by neurons, and aberrantly by certain tumor cells. These tumor-associated antigens can be presented to T cells, generating an antigen-specific immune response that leads to autoimmunity within the nervous system. In an animal […]