CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams03 G. Favre: Rho GTPases in tumor progression

03 G. Favre: Rho GTPases in tumor progression    03 G. Favre: Rho GTPases in tumor progression

  

Team Research Project

Team 3 (G. Favre): to determine how Rho GTPases control tumor progression

 

Our general aim is to understand the mechanisms involved in the deregulation of signaling pathways in cancerogenesis and their consequences in the response of antitumor therapy.

We focus primarily on RAS related GTPase RHOB that controls tumor progression of various cancers and emerged as an early DNA damage-inducible gene. However, very little is known about the mechanisms by whic RHOB exerts its different functions. To propose and validate new therapeutic strategies targeting Rho-dependant pathways, we develop basic, biotechnological, translational and clinical research.

We accumulated evidence that RHOB is a major player in oncology. We have shown that RHOB, by controlling PP2A activity, is important for DNA repair and the maintenance of genomic stability, and determines tumor aggressiveness in murine transgenic models. We identified RHOB as a new target to reverse the resistance to MAPK pathway inhibitors in lung cancer and melanoma. We also proposed RHOB as a biomarker to better predict the response to EGFR and MAPK inhibitors in lung cancer and melanoma, respectively.

To study specifically the role of active RHOB, we developed conformational sensors based on single chain antibodies and proposed a strategy to selectively knockdown active RHOB protein. We also developed a split-GFP biosensor in cells to monitor spatiotemporal RHOB activation and screen for RHO inhibitors.

We want now to identify the active RHOB-interacting proteins in the DNA damage response, and selectively inhibit RHOB activation in cellular and mouse models of lung cancer and melanoma. We have recently identified the RHO GTPase RND1 as an early damage-inducible gene, and C-JUN as a MAPK inhibitor-inducible gene.

We develop early phase clinical trials using combination of BRAF and AKT inhibitors in BRAFV600E mutated melanoma patients and EGFR and AKT inhibitors in EGFR mutated non-small cell lung cancer patients.

Together, we expect our approaches to bring new insights in the molecular signaling of oncogenic and stress genotoxic pathways and to develop new therapeutic strategies for lung cancer and melanoma.

Keywords

  • Oncogenic signaling
  • Ras related Rho GTPases
  • Cell stress and double strand Break signaling
  • Biotechnology, Nano bodies, Split GFP
  • Melanoma, Lung cancers
  • Translational research, Biomarkers, Clinical trials

Publications

Team members
ARMAND-LABIT
Virginie

   +33(0) 5 31 15 52 12 
Hospital Practitioner - PH
BOUBEKEUR
Nadia

   +33(0) 5 82 74 15 75 
Engineer - IE2

Catherine BOUCHENOT BOUCHENOT
Catherine

   +33 5 82 74 16 10 
Technician - T
Stéphanie CABANTOUS CABANTOUS
Stéphanie

   +33 5 82 74 16 15 
Researcher - CR1

Olivier CALVAYRAC CALVAYRAC
Olivier

   +33 5 82 74 16 10 
Post-doctoral fellow
CASANOVA
Anne

   + 33 5 31 15 52 07 
Technician - other

CHERIER
Julia

   +33 5 82 74 16 15 
Engineer - IR2
Patrick CHINESTRA CHINESTRA
Patrick

   +33 5 82 74 16 10 
Engineer - IE1

DELCOURT
Nicolas

   +33(0) 5 82 74 16 12 
University Teacher / Researcher - MCU
FARELLA
Magali

   +33 5 31 15 52 11 
Technician - AI

Gilles FAVRE FAVRE
Gilles

   +33 5 31 15 52 00 
Hospital Practitioner - PU-PH
FIGAROL
Sarah

  
PhD student

Rémi GENCE GENCE
Rémi

   +33 5 82 74 16 09 
Technician - AT/ATP
GROSJEAN
Sarah

   +33 5 82 74 16 15 
Engineer - IE1

GUIBERT
Nicolas

   +33 5 82 74 16 10 
PhD student
KELLER
Laura

   +33 5 82 74 16 09 
Hospital Practitioner - AH/AHU

KORAICHI
Faten

   +33 5 82 74 16 10 
PhD student
Isabelle LAJOIE-MAZENC LAJOIE-MAZENC
Isabelle

   +33 5 82 74 16 15 
University Teacher / Researcher - MCU

MAZIERES
Julien

   +33 5 67 77 18 31 
Hospital Practitioner - PU-PH
Claire MEDALE-GIAMARCHI MEDALE-GIAMARCHI
Claire

   +33 5 82 74 16 10 
Engineer - IE2

MEYER
Nicolas

   +33 5 31 15 52 32 
Hospital Practitioner - PH
Sylvie MONFERRAN MONFERRAN
Sylvie

   +33 5 82 74 16 15 
University Teacher / Researcher - MCU

Laetitia MOULY MOULY
Laetitia

   +33 5 82 74 16 10 
PhD student
Aurelien OLICHON OLICHON
Aurelien

   +33 5 82 74 16 14 
University Teacher / Researcher - MCU

Magdalena POHORECKA POHORECKA
Magdalena

   +33 5 82 74 16 09 
PhD student
Anne PRADINES PRADINES
Anne

   +33 5 31 15 52 11 
Researcher - other

SORDET
Olivier

   +33 5 82 74 16 11 
Researcher - CR1
Claudine TARDY TARDY
Claudine

  
Post-doctoral fellow

 
Events

 A dynamic unfolded protein response controls cortical neurogenesis
01/07/16 - Dr Laurent Nguyen - Salle C. Cazaux - 11:00 - 12:00

 The epigenetics of prostate cancer: from molecular mechanisms to biomarker signature of disease recurrence
24/06/16 - Dr Raffaella Santoro - Auditorium IUCT-O - 13:00 - 14:00
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