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Applying by yourself to CRCT (i.e. Master students) ?

Please send you full CV & cover letter at: accueil.crct@inserm.fr

Your application will be forwarded directly to CRCT's Team Leaders

 


 Post-doctoral Research Fellow - CRCT Team 4 T. Levade / N. Andrieu

Applications are invited for a two years post-doctoral position on the IMMUSPHINX project coordinated by the T. Levade and N.  Andrieu-Abadie’s team. This position is funded by the Transcan-2 translational cancer research program (EU framework programme Horizon 2020) and is available starting from April 2017 at the Cancer Research Center of Toulouse (CRCT, Inserm 1037, France).

 

Project abstract

Immune checkpoint inhibitors (ICI) have shown unprecedented and long-lasting anti-tumor responses, mainly in patients with metastatic melanoma. Nevertheless, novel strategies are urgently needed to increase the number of responders and prevent relapse in melanoma, and to propose new ICI-based treatments in other cancers. In addition, personalized therapies, based on robust prognostic and predictive biomarkers, are necessary to improve resource allocation and toxicity management. Our team has a long-standing knowledge of the sphingolipid (SL) metabolism. We recently discovered that SL metabolism is strongly altered in melanoma, leading to oncometabolites that modify the tumor microenvironment. The IMMUSPHINX project aims at developing new combined therapeutic strategies against melanoma, by targeting both SL metabolism and immune checkpoints, and identifying related prognostic and/or predictive biomarkers. It involves a multidisciplinary research consortium and brings together basic and clinical complementary teams located in France, Spain, Italy and Belgium (http://www.transcanfp7.eu/abstract/immusphinx.html).

 

Scientific environment:

The CRCT is located in a campus bringing together public and private stakeholders dedicated to cancer research and care. IMMUSPHINX benefits from a direct access to the core facilities of the CRCT (http://www.poletechno-crct.inserm.fr/en/), including: SPF animal facility, flow cytometry and cell sorting, cellular imaging (confocal microscope and video microscope), vectorology (biosafety L3 laboratory), proteomics, transcriptomics and bioinformatics. It also benefits from straight relationships with clinicians involved in cancer treatment at the Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-O).

 

Expected qualifications and experience:

The selected candidate will work in a collaborative environment including faculty members, oncodermatologists and biostatisticians involved in translational cancer research. He/She will also closely interact with the Italian and Belgian collaborators, and will spend short periods in their laboratories.

The expected qualifications and skills are:

 

  • A PhD, with a strong background in oncoimmunology and/or immunology
  • Prior  experience  in  flow  cytometry,  mouse  experimentation  and/or  human specimens is highly desirable.
  • Experience in molecular biology and /or cellular biology would be a plus.
  • Excellent written and verbal communication skills, a good English practice, a high degree of motivation with good organizational and analytical abilities will be required.

 

How to apply ?

Submit your application to nathalie.andrieu@inserm.fr before March 1st 2017, by including in one single pdf file: full CV, statement of research interests, list of publications and patents, and 2 recommendation letters.

 


 

 
Events

 Optical tomography of tissue: morphologic and metabolic contrasts
05/05/2017 - Dr Claude Boccara - Salle C. Cazaux - 11:00 - 12:00

 Postmitotic nuclear assembly: Role of human telomere tethering to the nuclear envelope for the reformation of a functional G1 nucleus
28/04/2017 - Dr Laure Crabbé - Salle C. Cazaux - 11:00 - 12:00
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