CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams18 J.E. Sarry / C. Récher: RESIST@ML - Drug Resistance, Stem Cells & Oncometabolism in Acute Myeloid Leukemia

18 J.E. Sarry / C. Récher: RESIST@ML - Drug Resistance, Stem Cells & Oncometabolism in Acute Myeloid Leukemia    18 J.E. Sarry / C. Récher: RESIST@ML - Drug Resistance, Stem Cells & Oncometabolism in Acute Myeloid Leukemia

Team Research Project

Team 18: (J.E.Sarry, C. Récher): to understand the drug resistance in acute myeloid leukemia

Despite a high rate of complete remission after treatment with genotoxic agents, the prognosis is very poor in human acute myeloid leukemia (AML). Indeed, 5-year overall survival is about 30 to 40% in patients younger than 60 years old and less than 20% in patients over 60 years. Front-line chemotherapy based on a combination of an anthracycline (eg. daunorubicin, DNR, or idarubicin, IDA) and a nucleoside analogue (eg. cytarabine, AraC) is highly effective in ablating leukemic cells, but distant relapses are observed in the majority of patients, characterized by a refractory phase during which no other treatment has shown any efficacy thus far (Tallman et al. 2005; Burnett et al. 2011). Relapses are caused by tumor regrowth initiated by resistant leukemic clones (RLCs). The biology of therapeutic resistance currently represents an active area of research. However, the molecular mechanisms underlying AML chemoresistance are still poorly understood, especially in the in vivo context.
The goal of our Team is to understand the causes of drug resistance for the development of new treatments eradicating RLCs and overcoming patient relapses. Our hypothesis is that RLCs have specific mitochondrial energetic and metabolic features mediated by metabolic interactions with stromal cells, which modulates their therapeutic resistance in the tumoral niche. For that, using diverse metabolomic, transcriptomic, pharmacological and functional approaches as well as patient samples and a newly developed AML-engrafted immunodeficient models (Sarry et al. 2011), we propose to 1/ elucidate the stemness and functional heterogeneity of RLCs in response to genotoxics in vivo, and to 2/ determine how reprogrammed mitochondrial energy and metabolic signaling networks drive the drug resistance of RLCs in vivo.

Jean-Emmanuel Sarry & Christian Récher's team is part of Oncodevice, IMODI, Labex TOUCAN & PHUC CAPTOR

Keywords

  • Leukemia
  • Drug resistance
  • Patient-derived xenograft
  • Stem cells
  • Mitochondria
  • Energetics
  • Metabolism
  • Signaling
  • Innovative therapeutics

Publications

 

 

 

Team members
AROUA
Nesrine

   05 82 74 17 34 
PhD student
BEYNE-RAUZY
Odile

   + 33 (0)5 82 74 17 36 
Hospital Practitioner - PU-PH

BOUTZEN
Héléna

   +33 5 82 74 16 36 
PhD student
Nicolas BROIN BROIN
Nicolas

   05 82 74 17 34 
Technician - T

FARGE
Thomas

   +33 5 82 74 16 37 
Engineer - IE2
HOSSEINI
Seyed Mohsen

   05 82 74 17 35 
Post-doctoral fellow

Latifa JARROU JARROU
Latifa

   05 82 74 17 34 
Technician - AT/ATP
LARRUE
Clément

   +33 5 82 74 17 35 
PhD student

LEMERCIER
Gabriel

   05 82 74 17 36 
PhD student
NICOLAU-TRAVERS
Marie-Laure

   +33 5 31 15 61 79 
Technician - AI

RÉCHER
Christian

   +33 5 82 74 16 21 
Hospital Practitioner - PU-PH
SALAND
Estelle

   +33 5 82 74 17 36 
Technician - AI

Jean-Emmanuel SARRY SARRY
Jean-Emmanuel

   +33 5 82 74 16 32 
Researcher - CR1
SERHAN
Nizar

   +33 5 82 74 16 29 
Post-doctoral fellow

STUANI
Lucille

   +33 5 82 74 16 37 
Post-doctoral fellow
VERGEZ
François

  
Hospital Practitioner - AH/AHU

Sonia ZAGHDOUDI ZAGHDOUDI
Sonia

   05.82.74.17.36 
Technician - AI
 
Events

 A dynamic unfolded protein response controls cortical neurogenesis
01/07/16 - Dr Laurent Nguyen - Salle C. Cazaux - 11:00 - 12:00

 The epigenetics of prostate cancer: from molecular mechanisms to biomarker signature of disease recurrence
24/06/16 - Dr Raffaella Santoro - Auditorium IUCT-O - 13:00 - 14:00
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