17 J. Guillermet-Guibert: SIGDYN Group - PI3K isoforms, Signalling & Cancerogenesis
Team Research Project
Team 17: (J. Guillermet-Guibert): to identify the role of PI3K isoforms in cancerogenesis
PI 3-kinases (PI3Ks) are key signal transduction enzymes which are generally considered to be excellent new targets for therapeutic interference. Mammals have multiple PI3K isoforms, each of them having a specific physiological role.
While global PI3K inhibitors are already tested in clinical trials for cancer applications, the implication of the different isoforms of PI3K in cancer is still unclear and intensely debated. Our aim is to increase the understanding of the complex relationship within the different isoforms of PI3K in cancer cell signalling in vivo, in order to better target and prevent secondary effects in this clinical context.
We focus our attention on two lethal pathologies with no treatment, pancreatic and ovarian cancers.
We study the isoform-specific role of the signalling enzymes PI3Ks using new unique mouse models in which each isoform of PI3K is genetically inactivated, or genetic inactivation human primary culture using gene therapy.
Team 17's research projects are funded and have received support from:
- Cancerogenesis: The formation of cancer
- Cell: The basic unit of any living organism.
- Cell biology: Dynamic discipline dedicated to the study of a cell in a global context- This discipline combines a variety of scientific fields such as molecular biology, biochemistry, biophysics, microbiology, physiology, developmental biology, cytology, and genetics--fields that were once almost completely independent of each other. Tumor biology corresponds to the study of tumor cells in a global context.
- Cell Signaling: Refers to intracellular and extracellular molecular events that conducts the transmission of a signal and end to a response of the cell.
- Downstream: Refers to cellular or molecular events that occur further along in the signaling pathway.
- G protein-coupled receptor: A transmembrane receptor that contains seven membrane-spanning helical domains and functions as a ligand-dependent GEF that activates heterotrimeric G proteins to interact with other signalling proteins.
- Phosphatidylinositol 3-kinase (PI3K): A family of related enzymes that add a phosphate group to phosphatidylinositol 3 (PI3), which is a downstream signaling molecule involved for example in survival/proliferative pathways mediated by growth factors.
- Phosphorylation: The metabolic process of introducing a phosphate group into an organic molecule. It is a modification which is involved in cellular signalling.
- Oncogenic: Giving rise to tumors (either benign or malignant) or causing tumor formation.
- Tumor-suppressor gene: A gene whose protein product is responsible for antiproliferative signals or anti-tumoral signals.
- Tumorigenesis: The production of tumors.