CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams16 E. Delabesse: Alteration of transcription factors in acute leukemias

16 E. Delabesse: Alteration of transcription factors in acute leukemias

Team Research Project

Team 16: (E. Delabesse): to understand how altered transcription factors drive leukemogenesis

The hematopoietic stem cell differentiation allow the production of blood cells. This process is finely regulated by extrinsic factors (adhesion molecules, cytokines) and intrinsic factors (transcription factors (TF)).
Deregulation of this process in the early stages of the differentiation can lead to the transformation of progenitor cells, leading to acute leukemia characterized by an early block of hematopoietic cell maturation (blasts) and an uncontrolled proliferation. We aim to:

  • identify new TF alterations,
  • study their influence on the normal differentiation and 
  • assess their role in the leukemic process.

Currently, major targeted therapies are targeting cytoplasmic pathways. In order to find new therapeutic targets, we aim to decipher the pathways relaying the PAX5 and GATA2 mutant oncogenic effects. To this purpose, we have in the past five years identified recurrent mutations of TF in patients with acute leukemia and, due to the high degree of conservation of TF between man and mouse, we are modeling these alterations at the cellular and animal levels.

Keywords

  • Acute leukemia
  • Transcription
  • Mutations
  • GATA2
  • PAX5

Publications

 

 

 

Team members
Cyril BROCCARDO BROCCARDO
Cyril

  
Researcher - CR1
Alicia CARRETTE CARRETTE
Alicia

   +33(0) 5 31 15 63 85 
Technician - AI

Eric DELABESSE DELABESSE
Eric

  
Hospital Practitioner - PU-PH
HEBRARD
Sylvie

  
Technician - T

LAGARDE
Stéphanie

   +33 5 31 15 62 19 
LUQUET
Isabelle

  
Hospital Practitioner - PH

PASQUET
Marlène

  
PhD student
Naïs PRADE PRADE
Naïs

  
Engineer - IR2

STRUSKI
Stéphanie

   +33 5 31 15 62 21 
 
Events

 12th GERLI international Lipidomics Meeting - Microbe and Host Lipids
12th GERLI international Lipidomics Meeting - Microbe and Host Lipids

 Cellular origin and mechanisms of pancreatic cancer
23/05/16 - Dr Axel Behrens - Auditorium IUCT-O - 10:00 - 11:00
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