CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams15 M. Bardiès : Multiresolution dosimetry for radiotherapy optimization

15 M. Bardiès : Multiresolution dosimetry for radiotherapy optimization

Team Research Project

Team 15: (M. Bardiès): to establish patient-specific dosimetry as a means to optimize targeted radiotherapy


Targeted RadioTherapy (TRT) currently involves administering fixed amounts of radioactive drug for all cancer patients (“one size fits all”), eventually modulated by patient’s weight of body surface area, but disregarding patient’s specific uptake and washout of the radiopharmaceutical.
Implementing patient-specific dosimetry, based on the actual pharmacokinetics of the patient would significantly improve efficacy while confining toxicity to acceptable levels.

With this aim, our team optimizes the dosimetric process at all scales (cell, tissue, body) by quantifying activity distributions and modelling radiation transport for various emitters (alpha, beta, Auger) used for TRT. 

Our project relies on funded national or international academic research programmes: PhysiCancer (2013-2015), ANR (2014-2018), MetroMRT (projects.npl.co.uk/metromrt/) (2013-2015), and industrial projects: Betalutin™ (2013-2016) and TheraneaM (ISI 2014-2018).

  • At the cellular level, we develop and validate specific low-range particle radiation transport to assess the impact of cell type and morphology on energy deposition in sub-cellular compartments.
  • Preclinical studies are performed within small-animal imaging facilities installed at Institut Universitaire du Cancer de Toulouse – Oncopole (IUCT-O):
    • We develop procedures to validate in vivo pharmacokinetics determination in longitudinal studies for a variety of radiolabeled vectors.
    • In parallel, we generate specific rodent dosimetric models to give account of energy delivered in small animal TRT.
  • At the clinical scale, we focus on the assessment of uncertainties associated with TRT dosimetry. Our project, DosiTest (www.dositest.com), is based on Monte-Carlo modelling of scintigraphic imaging and energy deposition in realistic anthropomorphic phantoms. 
    • We intend to perform a virtual, multicentric clinical trial to determine the critical steps associated with clinical dosimetry.

This fundamental research on radiation effects will be applied to TRT clinical trials implemented in Nuclear Medicine Depts at IUCT-O (Lutathera™, Xofigo™) and Toulouse University Hospital (Radioembolization), to individualize Nuclear Medicine therapies. 
Beside Nuclear Medicine, we intend to expand our research activities in direction of external beam radiotherapy and eventually proton-therapy (project Pericles).

Training

We participate to student education via Toulouse Master of Medical Physics http://rmgbm.free.fr

Keywords

  • Dosimetry: absorbed dose (J/kg, or Gy) assessment. For external beam radiotherapy, dosimetry is mostly based on reference measurements of the high-energy photon beams produced by the accelerators. In Nuclear Medicine, dosimetry relies on calculations performed after radioactive source localisation (quantitative scintigraphic imaging).
  • Monte-Carlo modelling: Assessment of radiation-matter interactions, based on the stochastic nature of radiation emission, transport and energy deposition. Heavily used in Medical Physics, both for imaging and dosimetry. Gate (http://www.opengatecollaboration.org) is one of the most popular codes in Nuclear Medicine.

Publications

 

Team members
Manuel BARDIÈS BARDIÈS
Manuel

   +33 5 62 88 90 81 
Researcher - DR2
Sara BEILLA BEILLA
Sara

  
PhD student

Marie-Claude BORDAGE BORDAGE
Marie-Claude

  
Researcher - CR1
Julien BORDES BORDES
Julien

  
PhD student

Richard BROWN BROWN
Richard


PhD student
CASSOL-CURNELLE
Emmanuelle

  
Hospital Practitioner - MCU-PH

CHATRIE
Frédéric

  
PhD student
COSTA
Gustavo

  
PhD student

Regis FERRAND FERRAND
Regis

  
Hospital Practitioner - PH
Xavier FRANCERIES FRANCERIES
Xavier

   +33(0)5 82 74 17 27 
University Teacher / Researcher - MCU

Sara MARCATILI MARCATILI
Sara

  
Post-doctoral fellow
MORA RAMIREZ
Erick

  
PhD student

Luc SIMON SIMON
Luc

   +33 5 31 15 54 89 
Researcher - other
TRANEL
Jonathan

  
PhD student

Laure VIEILLEVIGNE VIEILLEVIGNE
Laure

  
Hospital Practitioner - PH
YOUNES
Tony

  
PhD student

 
Events

 12th GERLI international Lipidomics Meeting - Microbe and Host Lipids
12th GERLI international Lipidomics Meeting - Microbe and Host Lipids

 Cellular origin and mechanisms of pancreatic cancer
23/05/16 - Dr Axel Behrens - Auditorium IUCT-O - 10:00 - 11:00
Tools
ContactContact
MapMap
DirectoryDirectory
Inserm Université Toulouse 3 - Paul Sabatier CNRS