CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams11 E. Cohen-Jonathan Moyal / C. Toulas: Glioblastoma radioresistance: from signalling pathways to clinical trials

11 E. Cohen-Jonathan Moyal / C. Toulas: Glioblastoma radioresistance: from signalling pathways to clinical trials    11 E. Cohen-Jonathan Moyal / C. Toulas: Glioblastoma radioresistance: from signalling pathways to clinical trials

Team Research Project

Team 11: (E. Moyal, C. Toulas): to decipher glioblastoma radioresistance mechanisms leading to clinical trials developed by the PI in IUCO radiotherapy department

This translational research team in radiobiology, specialized in optimizing the radiotherapy treatment of glioblastoma (GBM), is developing 3 complementary approaches i) first by deciphering the biological mechanisms of tumor radioresistance ii) by performing preclinical trials to validate targets for conceiving new radiosensitizer agents and to identify new predictive markers and iii) by designing and performing early phase clinical trials associating targeted drugs directed against the target identified in the lab with radiotherapy and integrating surrogate biomarkers as well as metabolic imaging studies. We focus our research on GBM stem cells (GSC) involvements in GBM radioresistance, by investigating radiation-induced GBM cell plasticity and GSC migration as well as hypoxia regulation and intracellular pathways of GSC radioresistance. Several preclinical and clinical trials designed from our results are under current.

Elizabeth Moyal & Christine Toulas' team is part of PHUC CAPTOR

Keywords

  • Glioblastoma
  • Radioresistance
  • Stem cells
  • Migration
  • Hypoxia
  • FGFR
  • Integrins
  • Preclinical trials
  • Early phase clinical trials

Publications

 

 

 

Team members
Florent ARNAUDUC ARNAUDUC
Florent

   +33 (0)5 82 74 16 02 
Technician - AT/ATP
BARICAULT
Laurent

   +33 5 82 74 16 04 
University Teacher / Researcher - MCU

BOYRIE
Sabrina

   +33 5 31 15 50 50 
PhD student
Elizabeth COHEN-JONATHAN MOYAL COHEN-JONATHAN MOYAL
Elizabeth

   +33 5 82 74 16 07 
Hospital Practitioner - PU-PH

COURTADE-SAïDI
Monique

   +33 5 31 15 61 94 
Hospital Practitioner - PU-PH
Pauline DESHORS DESHORS
Pauline

   +33 (0)5 82 74 16 02 
PhD student

EVRARD
Solène

   +33 5 31 15 62 07 
Hospital Practitioner - AH/AHU
Marie-Julie GHERARDI GHERARDI
Marie-Julie

  
Engineer - IE2

Valérie GOUAZÉ-ANDERSSON GOUAZÉ-ANDERSSON
Valérie

   +33 5 82 74 16 05 
Post-doctoral fellow
Aline KOWALSKI-CHAUVEL KOWALSKI-CHAUVEL
Aline

   +33 5 82 74 16 04 
Engineer - IR1

Anthony LEMARIÉ LEMARIÉ
Anthony

   +33 5 82 74 16 06 
University Teacher / Researcher - MCU
Laure MALRIC MALRIC
Laure

   05.82.74.16.03 
PhD student

PROJETTI
Fabrice

   +33 5 31 15 65 91 
Hospital Practitioner - AH/AHU
Julie SESEN SESEN
Julie

   +33 5 82 74 16 03 
PhD student

SEVA
Catherine

   +33 5 82 74 16 04 
Researcher - DR2
SKULI
Nicolas

  
Researcher - CR2

Christine TOULAS TOULAS
Christine

   +33 5 82 74 16 08 
Researcher - other
URO-COSTE
Emmanuelle

  
Hospital Practitioner - PU-PH

 
Events

 A dynamic unfolded protein response controls cortical neurogenesis
01/07/16 - Dr Laurent Nguyen - Salle C. Cazaux - 11:00 - 12:00

 The epigenetics of prostate cancer: from molecular mechanisms to biomarker signature of disease recurrence
24/06/16 - Dr Raffaella Santoro - Auditorium IUCT-O - 13:00 - 14:00
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