CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams10 P. Cordelier: Epigenetics & translational research in pancreatic diseases

10 P. Cordelier: Epigenetics & translational research in pancreatic diseases

Team Research Project

Team 10: (P. Cordelier): to define the role of epigenetics in pancreatic cancer and to devise new innovative strategies for cancer treatment

Pancreatic adenocarcinoma (PDAC) remains the fourth leading cause of cancer death and is one the most lethal of commonly diagnosed cancers. Our research effort is dedicated to better understand the early stages of carcinogenesis and to implement innovative therapeutic research for patients’ treatment, such as gene therapy. In greater details, we are currently exploring whether epigenetic profiles may help for patients (early) diagnosis, characterizing new key drivers involved in pancreatic carcinogenesis and/or resistance to standard-of-care and further encourage innovative therapeutic research programs for treatment of patients in clinical trials ‘early and phase II). This work is supported by unique experimental animal models and patient cohorts.

Keywords

  • Pancreatic cancer: tumor of the pancreas. If adenocarcinoma, tumor of the exocrine (acinar and duct cells) of the pancreas. Can also be endocrine (originating from the Langerhans islets).
  • Gene therapy: using genes to treat disease. Needs a vector, to enter the cell, that can be non-viral or viral, and a therapeutic gene (either for replacement of an anticongene or to target an oncogene, when applied to cancer therapy).
  • Clinical trials: experimentation in patients of cutting-edge and/or breaktrough treatments
  • Patient cohorts: collection of tissues, blood... sampled from patients for target validation or discovery.
  • Animal models: tumors developed in animals (most of the time mice) to mimic the human disease.
  • Biomarkers: small molecules (proteins, RNA, DNA, miRNA) that can be easily sampled from patients for diagnosis or prognosis to help manage their disease.
  • Epigenetics: non-genetic regulation of gene expression (above genetic)
  • Ubiquitin ligase: protein involved in the ubiquitination of proteins, a mechanism known to induce proteolysis and, as a consequence, to control gene expression.
  • Carcinogenesis : different phases (early and late) of tumor progression
  • MicroRNAs : small non-coding RNAs tightly controlling gene expression, that can serve as biomarkers or therapeutic targets (see above).

Publications

 

 

 

Team members
BOURNET
Barbara

   +33 5 82 74 16 40 
Hospital Practitioner - PH
BUSCAIL
Louis

   +33 5 82 74 16 42 
Hospital Practitioner - PU-PH

CACHEUX
Jean

  
PhD student
CARRERE
Nicolas

  
Hospital Practitioner - PU-PH

CASTEL-MOLIERES
Marion


Hospital Practitioner - AH/AHU
CONZATTI
Guillaume

  
PhD student

Pierre CORDELIER CORDELIER
Pierre

   +33 5 82 74 16 41 
Researcher - DR2
DUFRESNE
Marlène

   +33 5 82 74 16 43 
Researcher - DR2

GUIMBAUD
Rosine

  
Hospital Practitioner - PU-PH
Naïma HANOUN-ZIANE HANOUN-ZIANE
Naïma

   +33 5 82 74 16 40 
Engineer - IE1

KIRZIN
Sylvain

    +33 5 82 74 16 40 
PhD student
Dorian LARRIEU LARRIEU
Dorian

   +33 (0)5 82 74 16 40 
PhD student

Hubert LULKA LULKA
Hubert

  
Technician - T
SELVES
Janick

  
Hospital Practitioner - PU-PH

Jérôme TORRISANI TORRISANI
Jérôme

   +33 5 82 74 16 44 
Researcher - CR1
VINEL
Jean-Pierre

  
Hospital Practitioner - PU-PH

 
Events

 A dynamic unfolded protein response controls cortical neurogenesis
01/07/16 - Dr Laurent Nguyen - Salle C. Cazaux - 11:00 - 12:00

 The epigenetics of prostate cancer: from molecular mechanisms to biomarker signature of disease recurrence
24/06/16 - Dr Raffaella Santoro - Auditorium IUCT-O - 13:00 - 14:00
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