Team 6: (S. Pyronnet, C. Bousquet): Protein synthesis and secretion in oncogenesis
Results obtained during the last five years have led to the notion that the regulation of gene expression at the translational level plays an important role in the maintenance of the differentiation state of epithelial cells, specifically in the exocrine pancreas which synthesizes copious amounts of proteins destined for secretion. We have also found that alterations in the control of protein synthesis occur during epithelial carcinogenesis and may have potential therapeutic interests. These fundamental issues are tackled in tumors characterized by cancer and stroma cells where profound changes in secretion profiles arise during the process of carcinogenesis. We wish to add significant contributions in how the regulation of protein synthesis is connected to a secretory phenotype (fundamental research), how such fundamental mechanisms are involved in carcinogenesis (oncology research) and how they can be targeted for cancer treatment (translational research).
Stéphane Pyronnet & Corinne Bousquet's team is part of Labex TOUCAN & PHUC CAPTOR