CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams06 S. Pyronnet / C. Bousquet: Protein synthesis & secretion in carcinogenesis

06 S. Pyronnet / C. Bousquet: Protein synthesis & secretion in carcinogenesis    06 S. Pyronnet / C. Bousquet: Protein synthesis & secretion in carcinogenesis

Team Research Project

Team 6: (S. Pyronnet, C. Bousquet): Protein synthesis and secretion in oncogenesis

Results obtained during the last five years have led to the notion that the regulation of gene expression at the translational level plays an important role in the maintenance of the differentiation state of epithelial cells, specifically in the exocrine pancreas which synthesizes copious amounts of proteins destined for secretion. We have also found that alterations in the control of protein synthesis occur during epithelial carcinogenesis and may have potential therapeutic interests. These fundamental issues are tackled in tumors characterized by cancer and stroma cells where profound changes in secretion profiles arise during the process of carcinogenesis. We wish to add significant contributions in how the regulation of protein synthesis is connected to a secretory phenotype (fundamental research), how such fundamental mechanisms are involved in carcinogenesis (oncology research) and how they can be targeted for cancer treatment (translational research).

Stéphane Pyronnet & Corinne Bousquet's team is part of Labex TOUCAN & PHUC CAPTOR

Keywords

  • Protein synthesis: Biological process leading to protein fabrication in the cell
  • Secretion: Biological process leading to protein release from inside to outside the cell 
  • Translation initiation: One critical and controllable step of protein synthesis
  • Tumor microenvironment: Components which together with cancer cells compose a tumor

Publications

 

 

Team members
Corinne BOUSQUET-VAYSSE BOUSQUET-VAYSSE
Corinne

   +33 5 82 74 16 53 
Researcher - DR2
CARON
Philippe

  
University Teacher / Researcher - PU

Stéphanie CASSANT-SOURDY CASSANT-SOURDY
Stéphanie

   +33 5 82 74 16 50 
Technician - AT/ATP
DECAUP
Emilie

   +33(0)5 82 74 16 50 
Engineer - IR2

Pauline ESPAGNOLLE ESPAGNOLLE
Pauline

   +33(0) 5 82 74 16 51 
Technician - AI
FANJUL
Marjorie

   +33 5 82 74 16 53 
University Teacher / Researcher - MCU

JEAN
Christine

   +33(0)5 82 74 16 50 
Post-doctoral fellow
LACAILLE
Julie

   +33 (0)5 82 74 17 38 
PhD student

LACOSTE-COLLIN
Marie-Laetitia

  
Hospital Practitioner - MCU-PH
MARBOEUF
Catherine

   +33 5 82 74 16 51 
Technician - T

MARTINEAU
Yvan

   +33 (0)5 82 74 17 38 
Researcher - CR1
David MULLER MULLER
David

   +33 5 82 74 17 38 
PhD student

Stéphane PYRONNET PYRONNET
Stéphane

   +33 5 82 74 16 54 
Researcher - DR1
ROCHOTTE
Julia

   +33 5 82 74 16 50 
Engineer - IR2

Rémi SAMAIN SAMAIN
Rémi

   +33(0)5 82 74 16 50 
PhD student
Emeline SAROT SAROT
Emeline

   +33 5 82 74 16 54 
Engineer - IR2

STREHAIANO
Manon

   +33 (0)5 82 74 17 38 
VEZZOSI
Delphine

  
University Teacher / Researcher - MCU

 
Events

 Molecular mechanisms involved in pancreatic cell plasticity and cancer
30/09/16 - Dr Patrick Jacquemin - Salle C. Cazaux - 11:00 - 12:00

 Replication fork remodelling upon replication stress in cancer and stem cell
27/09/16 - Dr Massimo Lopes - Auditorium IUCT - 11:00 - 12:00
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