CRCT - Cancer Research Center of Toulouse
ResearchResearch Teams05. S.Millevoi:RNA-binding proteins and post-transcriptional regulation in cancer

05. S.Millevoi:RNA-binding proteins and post-transcriptional regulation in cancer

Research project

To understand the role of RBPs in post-transcriptional gene expression reprogramming in response to stress and to the deregulation associated to cancer pathobiology and resistance to treatments.

Alteration of post-transcriptional gene expression regulation is a hallmark of cancer. RNA-binding proteins (RBPs) are master regulators required for all post-transcriptional processes, including pre-mRNA splicing, polyadenylation, mRNA stability and translation. These factors allow dynamic regulation in normal and various stress conditions, and contribute to deregulations in the RNA metabolism of cancer cells. They can also directly impact genome instability by establishing a direct link between DNA- and RNA-mediated processes. RBPs recognize specific elements of diverse sequences and structures. Among these, RNA G-quadruplex structures have been shown to affect the expression of cancer relevant genes by modulating post-transcriptional steps.

Our research focuses on understanding the role of RBPs in post-transcriptional gene expression reprogramming in response to stress and to the deregulation associated to cancer pathobiology and resistance to treatments. We explore the role of RNA-protein interactions in cancer by integrating multiple layers of information based on multidisciplinary approaches, including 1) molecular mechanisms of regulation 2) genome-wide analysis of post-transcriptional regulations and of RNA-protein interactions 3) pre-clinical in vitro (spheroids) and in vivo analysis (xenografts models) and 4) clinical data from patients (Tissue microarray, TMA). We are also interested in developing small molecules that target cancer relevant post-transcriptional processes directed by specific RNA-protein interactions.

Stefania Millevoi's team is supported by:

 

Keywords

  • RNA-protein interactions
  • pre-mRNA processing
  • mRNA translation and stability
  • G-quadruplex
  • DNA damage response
  • metastasis
  • Drug resistance
  • Cancer gene expression

Publications

 

 

 

Team members
Raouia BEN NAYA BEN NAYA
Raouia

   +33 5 82 74 16 49 
Post-doctoral fellow
BONNET-MAGNAVAL
Florence

   +33 5 82 74 16 46 
PhD student

CABON
Florence

  
Researcher - DR2
Anne CAMMAS CAMMAS
Anne

   +33 5 82 74 16 49 
Researcher - CR2

HIÉBLOT
Corinne

   +33 5 82 74 16 45 
Engineer - IE1
Bernard KNIBIEHLER KNIBIEHLER
Bernard

   +33 5 82 52 57 25 
University Teacher / Researcher - PU

Guillaume LABROUSSE LABROUSSE
Guillaume

   +33 5 82 74 16 49 
PhD student
Eric LACAZETTE LACAZETTE
Eric

   +33 5 82 74 16 45 
University Teacher / Researcher - MCU

LE BRAS
Morgane


PhD student
Stefania MILLEVOI MILLEVOI
Stefania

   +33 5 82 74 16 45 
Researcher - CR1

Hervé PRATS PRATS
Hervé

   +33 5 82 74 16 47 
University Teacher / Researcher - PU
Julie TENET TENET
Julie

   +33 5 82 74 16 49 
PhD student

ZANIBELLATO
Catherine

   +33 5 82 74 16 46 
Technician - T
 
Events

 The many functions of RAS-PI3K signaling in lung cancer development
09/12/16 - Dr Esther Castellano - Salle C. Cazaux - 11:00 - 12:00

 From Drugs to Genes: implementing target free approaches in Cancer drug discovery
02/12/16 - Dr Ulf Nehrbass - Amphithéâtre IUCT-O - 13:00 - 14:00
Tools
ContactContact
MapMap
DirectoryDirectory
Inserm Université Toulouse 3 - Paul Sabatier CNRS